Cell technologiesThe human body consists of more than 200 different cell types, practically all of them have some specialization: nervous,
muscle, epithelium, endothelium, adipose, chondrogenic, osteogenic etc. Some cells restore rapidly, for example, skin cells and blood cells. Some cells stay invariable in the adult organism, they do not divide, for example cardiomyocytes. Previously the opinion was that nerve cells could not renew, however the latest development in biological science refutes this old dogma.
Historically eminent discoveries in biology and medicines were achieved due to the development of cell technologies. The capability of isolating cells from the organism and cultivating them in vitro is the basis of many new scientific approaches in medicine. Last years scientists paid much attention to the special reserve material of our body - stem cells.
Stem cellsStem cells and the discovery of their mechanism caused a real furore in practical and regenerative medicine. Stem cells (SC) are the fundamental constructive material of organisms, partaking in the regeneration processes. Every day about a billion cells are renewed in our body. New cells, the young generation, originating from SC replacing defective and outdated cells. SC niches are found practically in all tissues and organs. Their quantity and quality decreases with aging. Specifically this fact underlies aging conception in modern medicine. SC could be grown in vitro taken from different sources (bone marrow, adipose tissue, skin, muscle). SC have constant karyotype and gene expression for a long time, they are stable to infection. Absence of specialization is the basic characteristic of these cells. And they can differentiate into cells of different types under special conditions. Besides that they have high proliferative activity. The basic function of these cells is regeneration. Any inflammation processes in the organism, any error in systems activates stem cells. They are the main source of reserve material for our body taking part in reparation of different types of damage. Universal and unique simultaneously, these cells are the bricks of health, longevity and youth.
Embryonic stem cellsThere are embryonic and adult SC. ESC isolate form embryos at an early stage of development. They differentiate into all cell types of organism and have very high proliferative potential. Depending on the culture conditions, embryonic stem cells may form clumps of cells that can differentiate spontaneously to generate many cell types. This property has not been observed in cultures of adult stem cells. Also, if undifferentiated embryonic stem cells are removed from the culture dish and injected into a mouse with a compromised immune system, a benign tumour called a teratoma can develop. A teratoma typically contains a mixture of partially differentiated cell types. For this reason, scientists do not anticipate that undifferentiated embryonic stem cells will be used for transplants or other therapeutic applications. Besides that use of the human embryos as a source for therapy causes great ethical concerns. Stem cells of adult organisms, first discovered in 60th of past century by Russian scientist Alexander Fridenstein in bone marrow, have a great regenerative potential too. Recent scientific data tells about the presence of similar cells practically in all organs and tissues of the organism. The use of adult stem cells in the clinic has incontestable advantages. Especially for autologous transplantation without the risk of immune response and possible genetic defects of the donor material. It's possible to use adult stem cells without differentiation. The potential of undifferentiated cells is higher compared with progenitors.
The allogenic transplantation of mesenchymal stem cells (MSC) is possible using the screening of donor material. And it's evident in extraordinary situations or for very old patients. Pure culture of MSC does not have histocompatibility antigens and has immunosuppressive properties. Rare reactions from the immune system may be due to the presence of some part of progenitor and differentiated cells among stem cells in culture.
Dormant cellsMSCs are heterogeneous. It's a population of cells differing in morphology and potential. According to recent literature data among MSCs in vitro there are a population of small cells less than 10 micron. Their properties are similar to ESC. At the same time they have all the advantages of MSC for clinical use. Now these cells are the subject of deep scientific investigations. Receiving and cultivating them causes some difficulties but possibly they are that special seed in which nature's secret of youth, health and longevity is included.
RecoveryFor a long time scientists have tried to understand how the organism recovers after damage, how injured cells are restored after damage and which mechanisms underline this substitution. The understanding of the basis that mechanisms would help us to use them directly and intensify reparative potential of the organism. Nature gave us a unique mechanism for recovering using our own reserve cells. However we mostly use different chemicals for health obviously harmful for us and our cells.
Our patients often ask us: "if we have such unique cells in organisms why do we become ill" ? What is the mechanism of SCs action? In the organism they find inflamed regions and replace injured cells. If they fall into SC niches they enrich them and activate available SCs. Unfortunately not all cells get necessary places, some of them are lost.
By scientific data many diseases can be treated with SCs today: ischemic diseases, myocardium infarct, diabetes, hormonal disorders, genetic breaks. They are used for restoring different osteogenic injures, for the treatment of teeth, burns and different skin diseases. They are useful for the treatment of different nervous diseases, such as Parkinson's and Alzheimer's, for different injures of spine and brain. SCs are conductive to more rapid rehabilitation after chemotherapy in leukaemia.
RejuvenationAnother perspective area for the use of stem cells is aesthetic medicine. Their use improves the state of skin, intensify blood-thirstiness, reduce draws. Falling into SC s niches they can hold back ageing process. SCs take care of your beauty and health at the same time. Cosmetology and plastic surgery are special areas of SC s use. Cosmetology is now not just an aesthetic area of medicine. It's clear now that it is impossible to look good without good health. Modern aesthetic medicine is diagnostic and remedies not only aesthetic defects but diseases too. SCs application methods for recovery and rejuvenation.
All our patients pass through close diagnostic control. It includes blood analysis, immune and hormonal control, infection exposure. After diagnostics patient gives some material for cells separation. It may be bone marrow, ten to 15 ml aspirated from the iliac crest, or adipose tissue taken through a little slit of navel. Both do not keep any traces on the body after the procedure.
Cells are grown in a special laboratory conditions and may be used for different aims - systemic infusion or local.
Usually it takes from one to two months depending on quantity of necessary cells and their own proliferative activity. Cells may be frozen by patient's wish. Quantity of cells and procedures depends on individual features of organism and patient's wishes. Cell therapy nevertheless can t be considered as a panacea of all diseases. And it's clear that our therapy will give better results in combination with healthy mode of life. However it's obvious that today it is a new, natural, effective and safety method for recovering and rejuvenation.
OUR BEST RESULTS are in treating:
- ischemia ( heart, brain, limb)
- infarctum myocardium
- skin problems including psoriasis
- nerve degenerative diseases (Alzhaimer, Parkinson, neuralgia, multiple sclerosis)
- diabetes consequences
- bone-muscle diseasis
- immunological problems, low immunity
- gormonal disbalance
- cosmetological problems